Occupational health and safety factors are critical for conducting business in the industrial sector, as well as maintaining sustainable business practices in the social aspect. This research focuses on studying the guidelines for preparation for ISO 45001 certification and developing them into a structural equation model. The study utilised a combination of qualitative and quantitative approaches to gather data. A survey was conducted among representatives of safety committees responsible for OHS in industries certified under ISO 45001. The survey used a questionnaire and had a total of 500 respondents. The statistics used in this study include descriptive, inferential, and multivariate statistics. The study on the Guideline for Preparation for Certified ISO 45001 ranks the four components in order of importance as follows: 1) Workforce readiness component (  = 4.11) The most important observation is: Specify key safe work practices in the Job Description for all positions. 2) Alliance readiness component (  = 4.01) An important observation in ISO45001 is the need to collaborate with stakeholders. 3) Information readiness component (  = 4.00) The most important observation is KPIs to prepare a readiness plan. 4) Resource readiness component (  = 4.00). It is critical to consistently ensure that all equipment is prepared for use. The hypothesis testing results indicate no significant difference, at the 0.05 level, in the importance of preparation guidelines for small and medium-sized businesses compared to large businesses. The analysis of the developed structural equation model showed that it met the evaluation criteria and aligned with the empirical data. The chi-square probability value was 0.477, the relative chi-square value was 1.003, the goodness-of-fit index was 0.956, and the root mean square error of approximation was at a level of 0.002.